Chemoprevention of colon cancer: metaanalysis & systematic review of preclinical studies in rats & mice
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Meta-Analysis of Chemoprevention Studies with Beta-Carotene,
in Carcinogen-Initiated Rats and in Min Mice.
- [B-carotene / Rats table] shows the potency of beta-carotene on the incidence of colonic tumors in rats or mice
- B-carotene / Rats Figure shows the potency of beta-caroteneon the incidence of colonic tumors in rats or mice (funnel plot)
- No carotene study in Min mice [B-carotene / Min mice] : No study published on beta-carotene given to Apc mutated mice
Figures from Rat Data Table
An Explanation of Data Presented Above
Beta-carotene effect in carcinogen-injected rodents. The meta-analysis of four studies including 204 rats and mice showed that beta-carotene reduces colon tumour incidence in rodents: RR= 0.76 (p=0.005) [Table]. However, this RR was not significant using Random model analysis (0.72, p=0.11, Figure). No study of beta-carotene in Min mice was found in the litterature.
Extracted from the article: "Corpet D.E. & Pierre F., 2005, European Journal of Cancer, How good are Rodent Models of Carcinogenesis in Predicting Efficacy in Humans? Systematic Review and Meta-Analysis of Colon Tumour Chemoprevention in Rats, Mice and Men. in the press." Fetch the [preprint] (.pdf)
Abbreviations /Data Tables
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- Column "p": NS, Non Significant; MS, Marginally Significant; *, significant: p<0.05 (by Fisher's test).
Last line: Meta-analysis global p value, calculated by Chi-square test, without Yates correction for continuity.
- Columns 3 & 4: Number of tumor-bearing rats in control group (col.3); Total number of control rats (col.4). Control rats' data were duplicated in each line with treated rats data, although control rats were summed only once in last line. Duplicated numbers are tagged with a "-" (e.g., 15- )
- Meta-Analysis Methods, Rats:
See bottom of previous page on Meta Analysis
DE Corpet & F Pierre, 2005, European J. Cancer
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