Colonic Adenoma Reccurence Prevention, Chemoprevention Database
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Documentation on Men-Rats-Mice Data: in construction
How good are rodent models of carcinogenesis in predicting
efficacy in humans?
A systematic review and meta-analysis of
colon chemoprevention in rats, mice and men
- [MenRatsMice] table shows comparison of human trials with rodents' studies:
It was built when writing the article: Corpet DE, Pierre F, 2005 cited below. It should be updated, but it will be a huge work to do it properly, this is why it's labelled "in construction"
Mean potency of agents tested in volunteers to reduce also
- tumor incidence in azoxymethane initiated rats, and
- polyp number in Min mice
- RR (relative risk) or PR (polyp ratio) of "0.50" means that the agent halved the tumor endpoint.
It reduced the polyp recurrence in the treated group to 50% of the control group value.
1.00 denotes a no effect treatment. 1.20-1.60 means a tumor enhancing effect (promotion)
- Fetch full publication: [EJC] - [Free Article]
Corpet D.E. & Pierre F., 2005, European Journal of Cancer, How good are Rodent Models of Carcinogenesis in Predicting Efficacy in Humans? Systematic Review and Meta-Analysis of Colon Tumour Chemoprevention in Rats, Mice and Men.
The [Man] table is a summary of dietary prevention of intestinal tumors in humans. Fetch also Full Explanations on the [Man] table.
See also comments on the discrepancies between human's and rodent's studies, and full [Meta-Analysis] study of aspirin, calcium, wheat brand and beta-carotene effect in men, rats, and mice.
Corpet DE & Taché S, 2002, Nutrition & Cancer - & - DE Corpet & F Pierre, 2003, Cancer Epidemiol. Biomarkers Prevention.
E-mail: . Sites: Chemoprevention Database & Mirror site