Potency-Man

Potency-Man, last modif.: 24 Jul 2008 - Data sorted by " Daily dose" - Click column header to sort table or click HERE to select filtering rules - Go BACK to get explanation about column headers.

line #	Agent or Diet	Study Qual.	Reference (click name for abstract)	- RR -	Relative Risk (95% conf.int.)	size: treated number	Length, months	Daily dose	Fem. Male Both	Colon endpoint	Primary endpoint	Weighed mean /agent	Agent
H08	cox Celecoxib	top	Bertagnolli 06	0.55	0.55 (0.48-0.64)	671	36	800 mg	B	Adeno. rec.		0.67	cox
H10	cox Celecoxib	! SS	Steinbach 00	0.72	0.72 polyp/patient	30FAP	6	800 mg	B	Polyp no.	Polyp numbr	0.67	cox
H01	DFMO+sulindac	top	Meyskens 08	0.30	0.30 (0.18-0.49)	138	36	500+150	B	Adeno. rec.		0.30	D+sul
H09	cox Celecoxib	top	Arber 06	0.64	0.64 (0.56-0.75)	933	36	400 mg	B	Adeno. rec.		0.67	cox
H06	Sulindac sulfide	! EP	Arber 06	0.65	0.65 (0.43-0.99)	33	12	400 mg	B	Therap.resp.	Polyp size	0.65	ExS
H07	cox Celecoxib	top	Bertagnolli 06	0.67	0.67 (0.59-0.77)	685	36	400 mg	B	Adeno. rec.		0.67	cox
H21	Aspirin	top	Baron 03	0.96	0.96 (0.81-1.13)	372	33	325 mg	B	Adeno. rec.		0.85	Asp
H18	Aspirin	top	Sandler 03	0.65	0.65 (0.46-0.91)	317	31	325 mg	B	Adeno. rec.		0.85	Asp
H12	Sulindac	! SS	Giardiello 02	0.78	0.78 (0.4-1.5)	21FAP	48	300 mg	B	Polyp no.	Polyp numbr	0.78	Sul
H17	Aspirin	! SS	Benamouzig 03	0.61	0.61 (0.37-0.99)	60	12	300 mg	B	Adeno. rec.		0.85	Asp
H46	Vit.E	! EP	Lee 05	1.00	1.00 (0.77-1.31)	19937	121	200 mg	F	CRC incid.	Cardiovasc.	1.10	VitE
H03	Selenium	! EP	Clark 96	0.42	0.42 (0.18-0.95)	653	54	200 æg	B	CRC incid.	Skin cancer	0.64	Se
H34	Aspirin	! EP	Gann 93	1.15	1.15 (0.80-1.65)	11037	60	162 mg	M	CRC incid.	Cardiovasc.	1.04	Asp
H16	Aspirin	! EP	Gann 93	0.86	0.86 (0.68-1.10)	11035	60	162 mg	M	Adeno. Incid.	Cardiovasc.	0.85	Asp
H33	Aspirin	! NR	Sturmer 98	1.07	1.07 (0.67-1.70)	3489	144	162 mg	M	CRC incid.	All cancers	1.04	Asp
H20	Aspirin	! SS	Benamouzig 03	0.85	0.85 (0.57-1.26)	66	12	160 mg	B	Adeno. rec.		0.85	Asp
H04	Se,Ca,vitC,vitE,Bcar	! SS	Hofstad 98	0.71	0.71 (0.5-1.0)	42	36	100æg+1.6 g	B	Adeno. rec.	Polyp growth	0.64	SeMix
H05	Se,Zn,vitC,vitE,Bcar	! EP	Hercberg 04	0.71	0.71 (0.39-1.31)	2520	90	100æg+176mg	M	CRC incid.	All cancers	0.64	SeMix
H19	Aspirin	top	Baron 03	0.81	0.81 (0.69-0.96)	377	33	81 mg	B	Adeno. rec.		0.85	Asp
H32	Aspirin	! EP	Cook 05	0.97	0.97 (0.77-1.24)	19934	121	50 mg	F	CRC incid.	All cancers	1.04	Asp
H45	Vit.E	! EP	Malila 99	1.66	1.66 (1.19-2.32)	7768	78	50 mg	M	Adeno. Incid.	Lung cancer	1.10	VitE
H26	Wheat bran	top	MacLennan 95	1.20	1.2 (0.8-2.0)	150	48	+25 g	B	Adeno. rec.		0.98	bran
H29	Beta-carotene	top	Greenberg 94	1.01	1.01 (0.85-1.20)	359	48	25 mg	B	Adeno. rec.		1.01	Bcar
H11	cox Rofecoxib	top	Baron 06	0.76	0.76 (0.69-0.83)	1277	36	25 mg	B	Adeno. rec.		0.67	cox
H31	Beta-carotene	! EP	Hennekens 96	1.00	1 not signif.	11035	144	25 mg	M	All cancers	Cardiovasc.	1.01	Bcar
H02	Lactulose	! NP	Roncucci 93	0.41	0.41 (0.21-0.81)	61	18	20 g	B	Adeno. rec.		0.41	Lac
H28	Beta-carotene	! EP	Malila 99	0.98	0.98 (0.71-1.35)	7761	78	20 mg	M	Adeno. Incid.	Lung cancer	1.01	Bcar
H30	Beta-carotene	top	MacLennan 95	1.50	1.5 (0.9-2.5)	156	48	20 mg	B	Adeno. rec.		1.01	Bcar
H25	Wheat bran	top	McKeown 94	1.20	1.2 (0.6-2.2)	99	24	+15 g	B	Adeno. rec.		0.98	bran
H24	Wheat bran	top	Alberts 00	0.88	0.88 (0.7-1.1)	719	35	+11 g	B	Adeno. rec.		0.98	bran
H23	Ursodeoxycholic acid	top	Alberts 05	0.88	0.88 (0.73-1.05)	661	32	8-10 mg/kg	B	Adeno. rec.		0.88	Urso
H27	Wheat bran	! NP	Ishikawa 05	1.31	1.31 (0.87-1.97)	191	48	7.5 g	M	Adeno. rec.		0.98	bran
H49	Psyllium	top	Bonithon 00	1.67	1.67 (1.01-2.76)	198	36	3.5 g	B	Adeno. rec.		1.67	psyl
H22	Lactobacilus casei	! NP	Ishikawa 05	0.85	0.85 (0.56-1.27)	192	48	3x10E10	M	Adeno. rec.		0.85	L.cas
H47	Folic +B6+B12	! EP	Lonn 06	1.36	1.36 (0.89-2.08)	2758	60	2.5+50+1	B	CRC incid.	Cardiovasc.	1.24	Fol
H35	Fruits & veg.	top	Schatzkin 00	1.00	1.00 (0.90-1.12)	958	36	+2serv	B	Adeno. rec.		1.07	F&V
H13	Calcium	top	Bonithon 00	0.66	0.66 (0.38-1.17)	176	36	2 g	B	Adeno. rec.		0.79	Ca
H15	Calcium +Mix	! SS	Hofstad 98	0.71	0.71 (0.5-1.0)	42	36	1.6 g	B	Adeno. rec.	Polyp growth	0.79	Ca
H36	Fruits & veg.	! WI	Beresford 06	1.08	1.08 (0.90-1.29)	19541	97	+1.3serv	F	CRC incid.		1.07	F&V
H14	Calcium	top	Baron 99	0.85	0.85 (0.74-0.98)	464	18	1.2 g	B	Adeno. rec.		0.79	Ca
H37	Calcium +vit.D3	top	Wactawski 06	1.08	1.08 (0.86-1.34)	18176	84	1 g +400 UI	F	CRC incid.	Hip fracture	1.08	Ca
H44	Vit.C +vit.E +vit.A	! NP	Roncucci 93	0.16	0.16 (0.06-0.43)	70	18	1 g +70+9mg	B	Adeno. rec.		1.10	VitCEA
H48	Folic acid	top	Cole 07	1.04	1.04 (0.90-1.20)	501	36	1 mg	B	Adeno. rec.		1.24	Fol
H43	Vit.C + vit.E	top	Greenberg 94	1.08	1.08 (0.91-1.29)	380	48	1+0.4 g	B	Adeno. rec.		1.10	VitCE
H42	Vit.C + vit.E	! SS	McKeown 88	0.86	0.86 (0.51-1.45)	70	24	0.4+0.4 g	B	Adeno. rec.		1.10	VitCE
H38	Low fat	top	MacLennan 95	0.90	0.9 (0.6-1.5)	151	48	-7%	B	Adeno. rec.		1.08	Lfat
H40	Low fat	top	McKeown 94	1.20	1.2 (0.6-2.2)	99	24	-9%	B	Adeno. rec.		1.08	Lfat
H39	Low fat	top	Schatzkin 00	1.00	1.00 (0.90-1.12)	958	36	-10%	B	Adeno. rec.		1.08	Lfat
H41	Low fat	top	Beresford 06	1.08	1.08 (0.90-1.29)	19541	97	-11%	F	CRC incid.		1.08	Lfat

Corpet D.E. & Pierre F. 2005, Eur.J.Cancer. Updated 2008 - http://www.inra.fr/reseau-nacre/sci-memb/corpet/indexan.html

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