Intestinal polyp prevention in Min mice. Go to: http://corpet.net/min Data ranked by potency Corpet DE & Pierre F 2003, Cancer Epidemiol. Biomarkers Prevention, Updated 2008 Line # Treatment, dose (% or ppm of diet, or mg/kgBW) /mutation (if not Min) Cate- gory Author year (click name for abstract)-> Potency to reduce polyps N sml.int. polyps: Control sml.int. polyps: Treated small.int: Treated %Contrl p Colon polyps contr. Colon polyps treatd Colon: Treated %Contrl p Ratio: Sml.int. /Colon Duration: weeks Treatment (3-digits) or Additionnal results M001 sulindac 160ppm NSAI Boolbol 96->8653697 56.2 1 12 0.0 1.0 * 0.4 0.1 25 0.0 11.5 Sul M002 EKB-569 +sulindac 150 +37.5ppm combi Torrance 00->10973323 25.0 1 20 1.0 4.0 * 9 EKB+sul M003 piroxicam 200ppm NSAI Ritland 99->9934849 23.3 3 53 2.0 4.0 * 13-26 Pir M004 piroxicam 0.5mg/mouse/d NSAI Hansen-Pet. 02->11741743 20.0 1 49 2.0 5.0 * 1 Pir M005 EKI-785 +sulindac 300 +150ppm combi Torrance 00->10973323 19.2 1 17 1.0 5.0 * 9 EKI+sul M006 celecox+CeaVacc./minCea 0.1% combi+ Zeytin 04->15150127 18.2 1 38 2.1 5.5 * 18 celx+vac M007 piroxicam 200ppm NSAI Ritland 99->9934849 15.4 3 53 4.0 7.0 * 1.5 Pir M008 sulindac 320ppm NSAI+ Hansen-Pet. 00->11015469 14.6 1 34 2.3 6.8 * 1.3 0.1 8 * 0.9 7 sul M009 sulindac 320ppm NSAI Chiu McEnt. 97->9331087 12.9 1 41 3.0 7.0 * 0.8 0.3 33 0.2 11 Sul M010 pioglitazone 1600ppm Ppar+ Niho Takah. 03->14611672 11.6 1 71 6.1 8.6 * 1.1 0.1 9 * 0.9 14 pio M011 CD4+25+ lymphocytes 3x10E5cells other+ Erdman 05->15899788 10.5 1 46 4.4 10 * 3 lym M012 DFMO + celecoxib 0.5%+500ppm combi+ Zell Ignat. 06->17096347 8.3 1 32 4 12 * 10 /+42 dfmo+cel M013 EKB-569 150ppm /EGF Torrance 00->10973323 7.7 1 20 3.0 13 * 9 EKB M014 celecoxib 0.15% for 3wks NSAI+ Carothers 06->16778222 7.6 1 33 4 13 * 3 /+42 cel No long-term protec M015 CD4+45RBlo25+ lymphoc. 6x10E5 other+ Rao Pouta. 06->16397216 7.3 1 57 7.8 14 * once lym M016 lipitor HMGR +celecox 100+300ppm combi+ Swamy 04 7.1 1 14 * 12 in high fat diet M017 atorvastatin + celecoxib 100+300ppm combi+ Swamy 06->16849589 7.1 1 40 6 14 * 1.4 0.1 4 3.9 13 /+42 ato+cel M018 ursodeox.+sulindac 15-4500+75ppm combi Jacoby-Cole 02 6.9 2 18 3.0 15 * Urs+sul M019 R-flurbiprofen 10mg/kg/d gav. other+ Wechter 97->9331093 6.8 2 29 4.2 15 * 6 less potent when given b.i.d. M020 sulindac in diet 200ppm NSAI+ Yang Fan 03->12663524 6.7 1 37 3.4 9 * 0.4 2.1 525 * 0.0 9 Sul M021 sulindac 160ppm NSAI Ritland 99->10213222 6.5 1 84 13 16 * 11 Sul M022 piroxicam 200 or 220ppm NSAI Ritland 99->10213222 5.6 2 68 12 18 * 11 Pir M023 sulindac 75-150ppm NSAI Jacoby-Cole 02 4.5 2 18 4.0 22 * Sul M024 celecoxib 0.12% /F344 M rat apc1137- NSAI+ Amos-Land. 07->17360473 4.5 1 8 1 17 * 3.6 1.2 33 * 0.5 23 /+40 cel rats Pirc male M025 CD4+25+ lymphocytes 3x10E5cells other+ Erdman 05->15899788 4.3 1 63 15 23 * 3 lym M026 piroxicam 50ppm NSAI Jacoby Cole 00->10766173 4.1 1 22 5.0 23 * 1.5 0.6 40 0.6 7 Pir M027 celecoxib 300ppm NSAI+ Swamy 06->16849589 4.1 1 40 10 24 * 1.4 0.2 14 1.7 13 /+42 cel M028 tea, white + sulindac 1.5%+80ppm phyto+ Orner 03->12584176 4.0 1 30 6.0 20 * 1.0 1.7 167 0.1 12 tea+sul M029 indomethacin 10ppm NSAI+ Niho Mutoh 07->17546600 4.0 1 74 18 24 0.9 0.6 67 0.4 14 /+42 ind M030 p53 rescue CP-313198 200ppm other+ Rao-Malis. 04 4.0 1 25 * 10 p53 M031 sulindac 150ppm NSAI Torrance 00->10973323 3.9 1 17 4.0 26 * 9 Sul M032 catechin(+) 0.1-1% phyto Weyant 01->11196148 3.8 2 26 7.0 27 * 0.6 0.1 17 1.6 11 Cat M033 DFMO +piroxicam 1% +50ppm /N Jacoby Cole 00->10766173 3.7 1 42 11 27 * 9 DFM+pir M034 piroxicam 50-100-200ppm NSAI Jacoby 96->8631000 3.7 3 17 4.0 23 * 0.6 0.9 150 0.2 6 Pir M035 5ASA balzalazide 250mg/kg ? NSAI MacGregor 96->10853036 3.6 1 22 6.0 28 * 21 1.3 13 ASA M036 nimesulide /Apc1638Mlh1 400ppm NSAI+ Yang-Itano 04 3.5 1 4 0.6 16 * 0.2 0.5 250 0.1 26 nim M037 celecoxib 500-0.15% NSAI Jacoby Seib. 00->11016626 3.4 2 22 6.0 29 * 1.5 0.6 37 0.8 7 Cel M038 ursodeox. +sulindac 500 +75ppm combi Jacoby-Cole 02 3.4 1 18 5.0 30 * Urs+sul M039 R-flurbiprofen 10mg/kg/d gav. other+ Wechter 97->9331093 3.2 2 21 6.6 31 * 6 20mg very potent but toxic M040 MMP inh. A-177430 200mg/kg/d ip other+ Wagenaar 03->12778076 3.2 1 18 5.6 31 * 6 MMP+COX M041 DHA /Apc716 3% in female fat Oshima 95->7586174 3.2 1 219 68 31 * 7 DHA M042 MMPinh.+COX-2inh.ip 60+40mg/kg/d combi+ Wagenaar 03->12778076 3.1 1 13 4 33 * 6 additive effect M043 fish oil K85 0.4% in male fat Paulsen 97->9363998 3.0 1 108 36 33 * 1.0 1.6 160 0.2 17/+1 Fish M044 celecoxib 500ppm NSAI+ Zell Ignat. 06->17096347 2.6 1 32 11 34 * 10 /+42 cel M045 celecoxib /minCea.Tg 0.1% NSAI+ Zeytin 04->15150127 2.9 1 38 13 35 * 18 celx M046 curcumin 0.1% phyto Mahmoud 00->10783313 2.8 1 33 12 36 * 11 Cur M047 caffeic acid CAPE 0.15% phyto Mahmoud 00->10783313 2.7 1 33 12 37 * 11 CAP M048 folate /MinMsh2-- 8ppm vitB Song Sohn 00->10866310 2.7 1 299 111 37 * 1.7 0.6 35 1.0 8 /+3 Fol M049 piroxicam 50ppm NSAI Jacoby Cole 00->10766173 2.6 1 23 8 35 * 0.8 1.4 169 0.2 3.5/7 Pir M050 arginine 0.2% drinking water /N+ Zell Ignat. 06->17096347 2.5 0.6 0.2 39 * 2.5 10 /+42 arg M051 R-flurbiprofen 10mg/kg/2d gav. other Wechter 00->10680582 2.5 1 25 10 40 * 6 25w survival cont27% treat100 M052 sulindac in water 180ppm NSAI+ Yang Fan 03->12663524 2.5 1 37 11 30 * 0.4 3.8 950 * 0.0 9 Sul M053 COX-2 inh.A-285969 40-80mg/kg/d ip NSAI+ Wagenaar 03->12778076 2.5 2 16 6 40 * 6 MMP M054 NO-aspirin (NA-ASA) 100mg/kg/d i.r. /N+ Williams 04->14697260 2.4 1 25 10 41 * 3 NO-asp M055 NO-1886 LPL inducer 800ppm other+ Niho Mutoh 05->15710887 2.4 1 121 50 42 * 1.0 0.3 30 * 1.4 13 NO1 M056 wheat/bran, Madison 45-50% fibact+ Drankhan 03->15087272 2.4 2 24 10 42 * 0.6 0.2 38 1.1 10 high orthophenolic wheat M057 MF-tricyclic /Apc716 3.5-14mg/kg/d NSAI Oshima 96->8945508 2.3 2 424 187 44 * 1.8 0.3 19 * 2.3 8 MF-tri M058 tea extr.+sulindac 0.1%water+300ppm combi Suganuma 01->11206275 2.3 1 72 32 44 * 10 Tea+sul M059 sulforaph.300ppm+dibenzoylmeth.0.5% combi+ Shen Khor 07->17942926 2.3 1 52 22 43 * 0.8 0.0 5 * 9.0 10 /+35 sul+dib M060 R-flurbiprofen 5mg/kg/d gav. other+ Wechter 97->9331093 2.3 2 26 12 44 * 6 R-flur M061 guanidinoethyldisulfide 10-30mg/kg/d /N+ Mabley 04->15063141 2.2 2 47 21 45 * 2.3 1.3 57 * 0.8 8 gua M062 CD4+25+ lymphocytes 3x10E5cells other+ Erdman 05->15899788 2.2 1 63 29 45 * 0.4 lym M063 cellulose 5-10% vs.0 in 20%fat fibact Yu Whiteley 01->11478486 2.2 2 30 14 45 * 0.4 0.4 107 0.4 9 Cel M064 copper 6vs1ppm other Davis 00->10974406 2.2 1 47 22 46 * 1.0 0.3 27 1.7 13 Cop M065 DFMO 2% /N Erdman 99->10469614 2.2 1 45 21 46 * 3.5 3.2 92 0.5 9 DFM M066 MF-tricycl./MinMsh2ñ 13mg/kg/d NSAI Lal Ash 01->11507063 2.2 2 200 92 46 * 9.0 5.7 63 * 0.7 2.5 MF-tri M067 pioglitazone 200-400ppm Ppar+ Niho Takah. 03->14611672 2.2 2 71 33 46 * 1.1 0.6 50 0.9 14 pio M068 5ASA balzalazide 62-125mg/kg ? NSAI MacGregor 96->10853036 2.1 2 22 11 49 * 13 ASA M069 aspirin 250-500ppm NSAI Barnes 98->9558273 2.1 2 36 17 48 * 1.0 0.7 65 0.7 7 Asp M070 sulindac 0.6mg/mouse/d NSAI Hansen-Pet. 02->11741743 2.1 1 46 22 48 * 1 Sul M071 NO-1886 LPL inducer 400ppm other+ Niho Mutoh 05->15710887 2.1 1 121 58 48 * 1.0 0.4 40 * 1.2 13 NO1 M072 caloric restriction -40% other+ Mai Colbert 03->12702556 2.0 1 9 4 43 * 0.6 0.8 133 0.3 9 CR M073 dibenzoylmethane DBM 1% (licorice) phyto+ Shen Khor 07->17942926 2.0 1 52 26 50 * 0.8 0.3 40 1.3 10 /+35 dib M074 tea, green or white 1.5% phyto+ Orner 03->12584176 2.0 2 30 15 50 * 1.0 0.5 51 1.0 12 tea M075 bran rice 30% fibact+ Verschoyle 07->17211473 2.0 1 37 19 50 * 2.5 1.7 68 * 0.7 14 /+28 bran M076 meat beef low-fat 27% /female other+ Kettunen 03->12941845 1.9 1 56 29 51 * 10 Beef M077 cyanidin-3-glucoside 0.3% phyto+ Cooke 06->16823841 1.9 1 53 27 52 * 12 /+28 C3G M078 sulforaphane 600ppm phyto+ Shen Khor 07->17942926 1.9 1 52 27 52 * 0.8 0.2 19 * 2.7 10 /+35 sul M079 piroxicam /Apc1309 500ppm NSAI Quesada 98->9617344 1.9 1 31 16 52 * 2.6 1.5 56 * 0.9 10 Pir M080 wheat bran 5-10% vs0, in 20%fat fibact Yu Whiteley 01->11478486 1.9 2 30 16 53 * 0.4 0.6 143 * 0.4 9 Whe M081 EPA eicopentaenoid a. 3.1% fat+ Hansen-Pet. 00->11015469 1.9 1 34 18 52 * 1.3 0.9 69 0.8 7 EPA M082 sulindac 84ppm drink.water NSAI+ VanKranen 03->12881015 1.9 2 61 31 50 2.4 3.2 131 0.4 10 sul M083 PEG 3350 10% in water PEG+ Roy Gulizia 02->15374630 1.9 1 39 20 51 * 3.2 2.6 81 0.6 10 PEG M084 sulforaphane 6mcmol/d phyto+ Myzak 06->16407454 1.8 1 46 24 53 * 10 /+42 sulf M085 ZD6474 VEGFrec.tyr.kin. 50mg/kg/d /EGF Wilkinson 04 1.9 1 91 50 54 * 3.5 0.8 24 * 2.3 4 77% in polyp burden M086 SDA stearidonic acid 3.1% fat+ Hansen-Pet. 00->11015469 1.9 1 34 19 55 * 1.3 0.2 15 * 3.6 7 SDA M087 tyrosine kinase prodrug DMU-135 0.2% other+ Sale Tunst. 06->16505954 1.9 1 60 32 53 * 1.6 1.2 73 0.7 14 /+28 DMU M088 sulindac 200ppm in water NSAI+ Kang 03->12706854 1.9 1 58 28 48 3.7 5.3 143 0.3 10 sign.reduct. /cecal polyps M089 VEGF inhib. AZD2171 5mg/kg/d early other+ Goodlad 06->16782971 1.8 1 91 50 55 * 3.5 1.4 40 * 1.4 4 /+42 vegf early treated M090 carnosol 0.1% phyto+ Moran 05->15705912 1.8 1 33 18 55 * 0.1 0.2 200 0.3 10 car M091 CEA vaccine /minCea.Tg boost/mo. other+ Zeytin 04->15150127 1.8 1 38 21 55 * 18 vac M092 epigallocatechin gallate(-) .32%water phyto Ju-Bose 04 1.8 1 30 17 55 * 6 EGCG M093 sulindac 80ppm NSAI+ Orner 03->12584176 1.8 1 30 16 53 * 1.0 1.1 111 0.5 12 sul M094 sulindac 160ppm NSAI+ Emami 04->15314234 1.8 1 67 38 56 * 1.8 0.4 22 * 2.5 9 sul M095 celecoxib 0.15% NSAI Jacoby Seib. 00->11016626 1.8 1 23 11 48 * 0.8 2.0 253 0.2 3.5/7 Celx M096 DFMO 1% /N Jacoby Cole 00->10766173 1.8 1 42 24 57 * 9 DFM M097 EKI-785 300ppm /EGF Torrance 00->10973323 1.8 1 17 10 56 * 9 EKI M098 fish oil K85 0.4-1.2-2.5% female fat Paulsen 97->9363998 1.8 3 73 40 55 * 0.8 0.3 38 1.5 17/+1 Fish M099 rofecoxib /Apc716 25-75ppm NSAI Oshima 01->11245490 1.8 2 201 111 55 * 8 Rof M100 selenium p-XSC 10-20ppm other Rao Cooma 00->10753194 1.8 2 41 24 58 * 2.8 1.2 43 * 1.3 11 Sel M101 sphingomyelin &cer. 0.1% other Schmelz 01->11559543 1.8 3 56 31 56 * 1.4 0.7 50 * 1.1 8 Sph M102 sulindac 160ppm NSAI Huerta 02->11830528 1.8 1 17 9 51 * 4.5 3.0 67 0.8 10 Sul M103 uroguanylin 26 mcrg/mouse/d other Shailubhai 00->11016642 1.8 2 48 27 57 * 0.7 0.1 14 * 4.0 11 Uro M104 aspirin 500mcg/d NSAI+ Mahmoud 98->9706142 1.8 1 32 18 56 * 0.6 0.5 83 0.7 10 Asp M105 chafuroside (from ool. tea) 10ppm phyto+ Niho Mutoh 06->16630115 1.8 1 144 81 56 * 0.8 0.8 96 0.6 14 cha M106 celecoxib 0.12% /F344 F rats apc1137- NSAI+ Amos-Land. 07->17360473 1.7 1 1 1 133 1.3 0.3 23 * 5.8 23 /+40 cel rats Pirc female M107 Vaccinium myrtillus &vitis frz-dry 10% phyto+ Paivarinta 04 1.7 2 65 38 58 * 10 ad.size blueb.x1.1 ling.x0.7 M108 ICG-001 B-catenin inhib. 257mg/kg/d other+ Emami 04->15314234 1.7 1 67 39 58 * 1.8 1.1 61 1.0 9 ICG M109 epigallocatechin-3-gallate 0.16-0.32% phyto+ Ju Hong 05->16288056 1.7 4 29 17 58 * 1.0 0.9 90 0.6 11-14 EGCG M110 DFMO 0.5% drinking water /N+ Yerushalmi 06->16705737 1.7 1 41 24 58 * 0.5 0.7 136 0.4 10 /+42 dfmo M111 guar gum 5-10% vs0 in 20%fat fibact Yu Whiteley 01->11478486 1.7 2 30 18 59 * 0.4 0.4 93 0.6 9 Guar M112 mofezolac cox1 /Apc1309 0.12% NSAI+ Kitamura 02->12189188 1.7 1 47 28 59 * 1.5 1.0 67 0.9 8 large polyps more reduced M113 estradiol /ovariectomized 21æg/d other+ Javid 05->15579483 1.7 1 35 21 61 * 0.8 0.4 50 1.2 13 E2 M114 coumestrol /ovariectomiz. 100ppm other+ Javid 05->15579483 1.6 1 35 21 61 * 0.8 0.2 25 * 2.5 10 cou M115 curcumin postweaning 0.002 phyto+ Perkins 03->12778080 1.6 1 115 70 61 * 13 Cur M116 bran oil (wheat ) phyto+ Sang Ju 06->17177503 1.6 1 28 18 62 * 0.4 0.3 63 1.0 8 /+42 wbo duplicate st.less signif. M117 BB protease inhibitor 0.1-0.5% phyto Kennedy 96->8630994 1.6 2 11 7 63 * 0.6 0.4 67 * 0.9 13 /d-2 BBPI M118 piroxicam 200ppm NSAI Ritland 99->9934849 1.6 2 53 34 64 2-4d Pir M119 sc26196 /desaturase 100mg/kg/d other Hansen-Pet. 02->11741743 1.6 1 54 34 63 * 7 sc2 M120 soybean oil low- 5% vs.20, no fibr diet fat Yu Whiteley 01->11478486 1.6 1 30 19 62 * 0.4 0.2 57 1.1 9 soyoil M121 sulindac /Apc716 150ppm NSAI Oshima 01->11245490 1.6 1 201 125 62 * 100 0.6 8 Sul M122 wheat bran:fat 20:5 vs.3:20% /Apc716 fibact Hioki 97->9363991 1.6 1 211 135 64 * 2.0 0.7 36 * 1.8 7 Whe M123 glucosylceramide from soy 0.1% fat+ Symolon 02->15113963 1.6 1 43 27 63 * 1.2 0.8 67 0.9 8 half-effect at 0.025% M124 pioglitazone 100ppm Ppar+ Niho Takah. 03->14611672 1.6 1 71 45 63 1.1 1.0 91 0.7 14 pio M125 Mirtoselect (from bilberry) 0.3% phyto+ Cooke 06->16823841 1.6 1 62 40 64 * 12 /+28 Mir M126 aspirin prew.+curc.postw 500ppm+0.2% combi+ Perkins 03->12778080 1.5 1 132 86 65 * 13/-3 not better than each M127 ellagic acid 0.16% phyto+ Paivarinta 06->16800775 1.5 1 71 47 65 10 /+35 ell cloudberry no effect either M128 meat beef 27% low-fat dried other+ Kettunen 03->12941845 1.5 4 59 38 66 10 sign.reduct.in females 10 w M129 atorvastatin 100ppm HMGR inhib. other+ Swamy 06->16849589 1.5 1 40 27 67 * 1.4 0.6 43 1.6 13 /+42 ato M130 aminoguanidine 0.15% in water /N Ahn Ohshima 01->11731407 1.5 1 73 50 69 0.8 0.5 63 1.1 10 Ami M131 arginine deficient diet No arginine diet /N Ahn Ohshima 01->11731407 1.5 1 102 68 67 * 0.2 0.6 300 0.2 10 Arg M132 JTE-523 100ppm NSAI Sasai 00->10783317 1.5 1 123 84 68 * 8 JTE M133 PgEP4 antagonist 300ppm NSAI Mutoh 02->11782353 1.5 1 61 42 69 * 0.5 0.2 40 1.7 7 ONO M134 piroxicam 25-50-100ppm NSAI Jacoby Cole 00->10766173 1.5 3 42 28 66 * 9 Pir M135 sulindac 300ppm NSAI Suganuma 01->11206275 1.5 1 72 49 68 10 Sul M136 pioglitazone /Apc1309 100-200ppm Ppar+ Niho Takah. 03->14522940 1.5 2 36 24 67 * 0.6 0.5 75 0.9 6 pio M137 iNOS inhib. ono1714 50ppm /Min+dss /N+ Kohno 07->17417780 1.5 1 53 37 71 4.6 1.4 31 * 2.3 5 /+42 NOS /DSS M138 troglitazone /Apc1638Mlh1 0.2% Ppar+ Yang Fan 05->15818612 1.5 1 4 1 35 0.2 1.3 813 * 0.0 26 tro M139 olive oil + fruits & veg. 11%+10% other+ Mai Colbert 03->12702556 1.5 1 9 6 67 * 0.6 0.5 83 0.8 9 mediterranean M140 inulin 10% fibact+ Kettunen 03->12941845 1.5 2 58 40 68 10 larger adenoma inulin grp M141 tricin (from rice bran) 0.2% phyto+ Cai AlFay. 05->16170019 1.5 1 21 14 67 * 0.3 0.6 200 0.3 14 Tri M142 nimesulide cox2 /Apc1309 400ppm NSAI+ Kitamura 02->12189188 1.5 1 47 32 68 * 1.5 1.2 80 0.9 8 larger polyps more reduced M143 flaxseed mix (59%fat) 15% phyto+ Oikarinen 05->16197574 1.5 1 54 37 69 * 0.3 0.4 127 0.5 10 fla M144 FP15 (rid peroxynitrite) 1-3mg/kg/d /N+ Mabley 04->15063141 1.4 2 47 33 70 * 2.3 1.3 57 * 1.2 8 FP15 M145 DHA docohexanenoic 3.1% fat+ Hansen-Pet. 00->11015469 1.4 1 34 23 69 1.3 1.6 123 0.6 7 DHA M146 exercise (treadmill) 1.1km/1h/d males other+ Mehl 05->15894538 1.4 1 93 66 71 * 9 Exer M147 aspirin 400ppm NSAI Sansom 01->11585736 1.4 1 34 25 74 53 /-3 Asp M148 celecoxib 150-500ppm NSAI Jacoby Seib. 00->11016626 1.4 3 23 17 73 * 1.1 0.7 65 1.1 3.5/-7 Celx M149 fish oil K85 1.25-2.5% in male fat Paulsen 97->9363998 1.4 2 108 80 74 1.0 0.7 65 1.1 17/+1 Fish M150 lignan HMR 200ppm /inulin diet phyto Oikarinen 00->10996730 1.4 1 40 27 67 * 1.3 1.7 131 0.5 5.5 Lign M151 selenium in broccoli 2.1ppm Se other Davis 02->11823596 1.4 1 67 48 71 * 1.9 0.4 22 * 3.2 10 Sel M152 ursodeoxycholic acid 500-0.15% other Jacoby-Cole 02 1.4 2 18 13 73 * Urs M153 mofezolac cox1 /Apc1309 600ppm NSAI+ Kitamura 04->14991580 1.4 1 58 42 72 4 polyp area 17% reduction M154 wheat/bran, 3 cultivars 45-50% fibact+ Drankhan 03->15087272 1.4 5 24 17 73 0.6 0.4 65 1.1 10 medium orthophenolic wheat M155 resveratrol 0.2% phyto+ Sale Tunst. 05->15688382 1.4 1 106 80 75 * 9.0 4.2 47 * 1.6 12 resv 0.05% no effect M156 exercise (volunt.wheel run.) 3.8km/d other+ Colbert 06->16699175 1.4 1 20 15 77 * 2.1 0.8 36 * 2.1 10 /+42 exer negative energy balance M157 DFMO 0.5% /N+ Zell Ignat. 06->17096347 1.4 1 32 24 73 10 /+42 dfmo M158 cherries 20% freeze-dried phyto+ Kang Seera. 03->12706854 1.4 1 58 42 72 3.7 3.3 89 0.8 10 sign.reduct. /cecal polyps M159 resveratrol analog. DMU-212 0.2% phyto+ Sale Tunst. 05->15688382 1.3 1 106 82 78 * 9.0 4.6 51 * 1.5 12 DMU 0.05% no effect M160 PgEP1+4 ant. /Apc1309 400+400ppm NSAI+ Kitamura 03->12841871 1.3 1 38 29 76 6 polyp area 56% reduction M161 chenodeoxycholic ac. 0.5% other Mahmoud 99->10069468 1.3 1 33 25 77 * 0.4 0.6 150 0.5 10 Che M162 folate 8-20ppm vitB Song Medline 00->11034085 1.3 2 24 19 80 4.6 3.7 80 1.0 13 /+3 Fol M163 rye bran 10% fibact Mutanen 00->10837006 1.3 1 35 26 75 * 1.8 1.4 78 1.0 5.5 Rye M164 sulindac /MinMsh2ñ 13mg/kg/d NSAI Lal Ash 01->11507063 1.3 1 44 33 74 4.8 5.0 104 0.7 22 Sul M165 tea green- extract 0.1% in water phyto Suganuma 01->11206275 1.3 1 72 56 78 10 Tea M166 sulindac sulfone 50mg/kg/d gav. other Wechter 00->10680582 1.3 1 25 20 77 6 no effect on tumor area M167 SNAIL AS-PMO 10mcg/gBW ip 5d/7 other+ Roy Iversen 04->15367710 1.3 1 26 20 78 * 6 sna M168 flaxseed +rapeseed oil 9% fat+ Oikarinen 05->16197574 1.3 1 54 42 78 0.3 0.4 127 0.6 10 fla M169 resveratrol 90mg/kg phyto+ Ziegler 04->14704285 1.3 1 33 26 79 7 resv M170 aspirin preweaning 500ppm NSAI+ Perkins 03->12778080 1.3 1 132 104 79 * 3/-3 Asp M171 green tea 0.6% drink /Min+AOM phyto+ Issa Volate 07->17638923 1.2 1 39 32 82 1.8 0.9 50 * 1.6 8 /+56 tea no regression M172 bezafibrate /Apc1309 100-200ppm Ppar+ Niho Takah. 03->14522940 1.2 2 37 30 81 * 0.7 0.5 71 1.1 6 100ppm N.S. effect M173 PgEP1 ant. /Apc1309 400ppm NSAI+ Kitamura 03->12841871 1.2 1 38 32 82 6 polyp area 12% reduction M174 germ-free status germ-free other Dove Clipson 97->9041176 1.2 1 32 28 88 1.4 0.9 66 1.3 12 Germ M175 IQ /Apc716 300ppm HAA Oshima 96->8561861 1.2 1 254 213 84 11 IQ M176 lactoferrin bovine 0.2% or 2% other Ushida 98->10025873 1.2 1 54 44 82 1.2 1.0 83 1.0 8 Bov M177 MeIQx /Apc716 400ppm HAA Oshima 96->8561861 1.2 1 254 221 87 11 MeIQx M178 rutin-quercetin 2% phyto Mahmoud 00->10783313 1.2 2 33 28 85 11 Rut M179 sulindac /Apc716 12mg/kg/d NSAI Oshima 96->8945508 1.2 1 424 356 84 1.8 0.9 50 1.7 8 Sul M180 sulindac /MinMsh2-- 13mg/kg/d NSAI Lal Ash 01->11507063 1.2 1 354 294 83 * 13.0 14.0 108 0.8 4 Sul M181 VEGF-A inhib. Mab G6-31 other+ Korsisaari 07->17553957 1.2 1 120 100 83 6 /+91 vegf tumor burden 7-fold reduction M182 PJ34 PARP inhibitor 3-10mg/kg/d /N+ Mabley 04->15063141 1.2 2 47 40 85 * 2.3 1.4 61 * 1.4 8 low dose NS M183 mushroom extr. Lsy16 400mg/kgBW phyto+ Merkel 06 1.2 1 17 15 86 6.5 mush M184 EGF epid.growth factor 223mcrg/Kg/d other+ Bashir 03->12749762 1.2 1 75 65 87 2.9 2.6 90 1.0 4 EGF +40% burden in duoden. M185 indomethacin /Apc1309 10ppm NSAI+ Kitamura 04->14991580 1.1 1 58 51 88 4 polyp area 46% reduction M186 flaxseed 0.5% phyto+ Oikarinen 05->15278371 1.1 2 57 51 89 1.0 0.6 63 1.4 7 fla M187 exercise (treadmill) 0.9km/45min/d other+ Colbert 03->14523302 1.1 2 8 7 88 0.4 0.6 150 0.6 5.5 Exer M188 acarbose /Apc1309 400ppm phyto Quesada 98->9617344 1.1 1 31 29 93 2.6 2.2 84 1.1 10 Aca M189 curcumin 0.2% phyto Collett 01->11323404 1.1 1 14 13 94 10 Curc M190 exercise 1.2 km/1h/d other Colbert 00->11039641 1.1 1 37 33 89 3.2 2.4 75 1.2 7 Exer M191 food restriction 20% restriction other Kakuni 02->11927003 1.1 1 55 51 93 2.3 1.1 48 2.0 7 FR M192 fructo-oligosaccharide 5.8% fibact Pierre 97->9000559 1.1 1 50 47 93 2.1 0.7 33 * 2.8 6 FOS M193 rye bran 10% /inulin diet fibact Oikarinen 00->10996730 1.1 1 40 36 91 5.5 Rye M194 vegetables-fruits mix. 20% in 9%fat phyto VanKranen 98->9771930 1.1 2 17 14 82 1.5 2.3 152 0.5 16/-3 Veg M195 wheat bran 7% fibact Pierre 97->9000559 1.1 1 50 47 94 2.1 1.5 71 1.3 6 Whe M196 PgEP4 ant. /Apc1309 400ppm NSAI+ Kitamura 03->12841871 1.1 1 38 35 91 6 polyp area 43% reduction M197 aspirin /Apc1638 300ppm NSAI+ Williamson 99->10334197 1.1 2 2.38 2 91 20 Asp pooled +RS&-RS M198 genistein /ovariectomized 0.001 other+ Javid 05->15579483 1.1 1 35 32 92 0.8 0.5 63 1.5 10 gen M199 folic acid defic.0.3 vs.2ppm /min Rcf1+/+ vitB+ Lawrance 07->16963246 1.1 1 60 56 92 10 /+23 folic deficiency M200 flaxseed 5% phyto+ VanKranen 03->12881015 1.1 2 15 14 93 1.4 1.2 89 1.1 10 high lignans & isoflavones M201 leptin 800æg/kg other+ Aparicio 05->15857934 1.1 1 123 115 93 1.3 0.9 69 1.4 6 Lep M202 mofez+nimes /Apc1309 600+400ppm NSAI+ Kitamura 04->14991580 1.1 1 58 55 95 4 polyp area 37% reduction M203 calcium, low (con./2) 0.25% vs 0.5% miner+ Huerta 02->12772782 1.0 1 12 11 92 3.4 3.7 109 0.8 12 ca M204 resveratrol 500ppm phyto+ Sale Richard 04 1.0 1 97 14 res M205 CLA-mix or -t10c12 1% fat+ Mandir 08->18336472 1.0 2 72 77 106 9.1 3.3 36 * 2.9 8 /+42 CLA protect prox.sml.intest. M206 arachidonic acid 1% fat Hansen-Pet. 02->11741743 1.0 1 54 55 101 7 Arach M207 Citrobacter rodentium 10E8 cfu once fibact Newman 01->11424022 1.0 1 9 7 79 0.8 2.8 350 * 0.2 22 Citr M208 fat high- LowFiber fat:cell. 22:0 vs.7:5% fat Mutanen 00->10837006 1.0 1 35 34 98 1.8 1.4 78 1.3 5.5 HF LF M209 fiber high- chow fibr:fat 18:6 vs.0:20% fibact Yu Whiteley 01->11478486 1.0 1 29 28 96 0.4 1.1 271 * 0.4 9 chow M210 methionine 0.7% other Paulsen 01->11848484 1.0 1 26 25 96 0.5 0.9 180 0.5 4 Met M211 Ro26-9114 3 x 5 mcrg/wk vitAD Huerta 02->11830528 1.0 1 17 17 102 4.5 4.7 104 1.0 10 Ro26 M212 soy isoflavones 475ppm vs 16ppm phyto Sorensen 98->9751277 1.0 2 31 31 99 11 soy M213 starch resistant- 19% fibact Pierre 97->9000559 1.0 1 50 50 99 2.1 3.0 143 0.7 6 starc M214 sulindac /Apc1638Mlh1 200ppm NSAI Itano 04 1.0 1 100 0.1 1.0 1111 * 0.0 26 incidence data M215 vit. D3 1a,25(OH)2-D3 3x0.01mcrg/wk vitAD Huerta 02->11830528 1.0 1 17 18 108 4.5 4.0 89 1.2 10 D3 M216 wheat bran 10% fibact Mutanen 00->10837006 1.0 1 35 35 99 1.8 2.1 117 0.9 5.5 Whe M217 aspirin 25 mg/kg NSAI+ Reuter 02->12171603 1.0 1 61 62 102 1.9 2.5 132 0.8 14 Asp M218 secoisolariciresinol (lignan) 200ppm phyto+ Pajari 06->16000235 0.9 1 51 54 106 0.5 0.4 80 1.3 10 seco M219 celecoxib 0.15% for >3months NSAI+ Carothers 06->16778222 0.9 1 33 35 106 18 /+42 cel No long-term protec M220 ALA alpha linolenic ac. 3.1% fat+ Hansen-Pet. 00->11015469 0.9 1 34 36 108 1.3 0.8 62 1.8 7 ALA M221 caffeine 440ppm phyto+ Ju Hong 05->16288056 0.9 1 29 31 107 0.7 0.8 114 0.9 6 caf M222 caloric restr. -30% /Mlh1 -30% other+ Tsao Dudley 02->12419828 0.9 1 2 2 108 * 43 CR M223 exercise (wheel) 4.7km/d males other+ Mehl 05->15894538 0.9 1 93 103 111 9 Exer M224 cherry cyanidin/anthocyan. 2-800ppm phyto+ Kang 03->12706854 0.9 2 58 65 112 3.7 3.4 92 1.2 10 sign.reduct. /cecal polyps M225 aspirin 200ppm NSAI Sansom 01->11585736 0.9 1 34 39 115 19 Asp M226 folate +choline 2ppm +3% vs 0+1.4% combi Sibani 02->11756224 0.9 3 29 33 114 10 Fol+cho M227 PEG 8000 /MinMsh2 5% PEG Naigamwal. 00->11156379 0.9 1 12 13 104 0.0 0.7 3020 * 0.0 9 PEG M228 PhiP /Apc716 400ppm HAA Oshima 96->8561861 0.9 1 147 168 114 8 PhiP M229 PhiP 50mg/kg x 4 inj. HAA Steffensen 97->9163695 0.9 2 72 78 108 0.7 0.5 78 1.4 4 PhiP M230 troglitazone Ppar-gam 150mg/kg/d Ppar Lefebvre 98->9734399 0.9 1 22 23 104 0.6 1.7 283 * 0.4 8 Trog M231 fat high-corn oil 15% vs 5% fat+ Mai Colbert 03->12702556 0.9 1 9 10 118 0.6 0.2 33 3.5 9 fat M232 resveratrol 90mg/kg phyto+ Ziegler 04->14704285 0.9 1 55 63 115 2.0 2.0 100 1.1 7 no effect of doses 4 & 20 M233 arginine 2% /N+ Yerushalmi 06->16705737 0.9 1 41 47 114 0.5 0.9 172 * 0.7 10 /+42 arg M234 VEGF inhib. AZD2171 5mg/kg/d late other+ Goodlad 06->16782971 0.8 1 63 73 116 4.0 5.7 145 0.8 4 /+70 vegf late treated M235 DFMO 0.5%+arginine vs. arginine 2% /N+ Yerushalmi 06->16705737 0.8 1 47 56 120 0.9 0.5 55 * 2.2 10 /+42 dfm/+arg M236 rye bran /male 30% phyto+ VanKranen 03->12881015 0.8 1 63 76 120 2.8 2.8 100 1.2 10 high lignans M237 calcium, high (con.x2) 1% vs 0.5% miner+ Huerta 02->12772782 0.8 1 12 14 121 3.4 3.9 115 1.1 12 ca M238 nimesulide cox2 /Apc1309 400ppm NSAI+ Kitamura 04->14991580 0.8 1 58 70 120 4 polyp area 25% reduction M239 aspirin 400ppm NSAI+ Chiu 00->10883057 0.8 4 31 37 120 6 Asp M240 rye bran insoluble fract. 8% fibact+ Oikarinen 03->12844383 0.8 2 31 38 123 0.5 0.9 180 0.7 6 rye bran insoluble fract. M241 vitamin mix low RDA/3 vitAD+ Bashir 04->15016659 0.8 1 58 72 123 * 1.6 2.2 140 0.9 8 vit M242 ethanol 17.5% in water other+ Roy Gulizia 02->12433735 0.8 1 27 37 138 * 4.7 2.4 51 2.7 10 eth M243 5ASA or 4-ASA 500ppm NSAI Ritland 99->10213222 0.8 2 84 102 122 11 ASA M244 bran oat 10% fibact Mutanen 00->10837006 0.8 1 35 47 133 1.8 1.8 100 1.3 5.5 Oat M245 BRL49,653 20mg/kg/d Ppar Lefebvre 98->9734399 0.8 1 27 31 113 0.6 3.2 525 * 0.2 8 BRL49 M246 folate 2-8-20ppm vitB Song Medline 00->11034085 0.8 3 18 23 126 2.6 3.1 120 1.0 26 /+3 Fol M247 inulin 10% fibact Pajari 02 0.8 1 55 68 123 0.6 1.3 211 0.6 9 Inulin M248 troglitazone Ppar-gam 0.2% Ppar Saez Tonton. 98->9734400 0.8 1 67 78 116 1.0 3.0 300 * 0.4 5 Trog M249 bexarotene 800ppm vitAD+ Merkel 06 0.8 1 16 20 126 6.5 bex M250 NOS2-/- vs NOS2+/+ /N+ Scott 01->11606502 0.8 1 34 44 129 * 1.8 1.3 72 1.8 18 N0S2-/- M251 matairesinol (lignan) 200ppm phyto+ Pajari 06->16000235 0.8 1 51 67 131 0.5 0.4 80 1.6 10 tum.size x1.17 M252 lithium 0.24% miner+ Gould 03->12770514 0.8 1 20 25 126 0.9 2.2 244 * 0.5 9 +16% tumor diameter * M253 CLA conjug.linoleic ac. 3% fat+ Hansen-Pet. 00->11015469 0.8 1 34 45 135 1.3 1.1 85 1.6 7 CLA M254 prostaglandin E2 2x 150mcg/d po other+ Wang Wang 04->15380519 0.7 1 50 64 128 * 0.3 3.3 1000 * 0.1 7 PGE2 incr. Polyp size M255 vitamin mix high=RDAx5 vit.RDA x 5 vitAD Bashir 04->15016659 0.7 1 58 78 134 * 1.6 1.8 114 1.2 8 vit M256 GLA gama linolenic ac. 3.1% fat+ Hansen-Pet. 00->11015469 0.7 1 34 47 139 1.3 1.2 92 1.5 7 GLA M257 rye bran 10% fibact+ Oikarinen 03->12844383 0.7 2 31 42 135 0.5 1.3 260 * 0.5 6 rye M258 folic acid defic.0.3 vs.2ppm /min Rcf1+/- vitB+ Lawrance 07->16963246 0.7 1 30 43 141 10 /+23 folic deficiency M259 corn oil 10% vs 3% fat Wasan 97->9096389 0.7 2 23 32 137 * 1.8 3.8 212 * 0.6 21-43 Oil M260 DHA /Apc716 3% in male fat Oshima 95->7586174 0.7 1 193 278 144 7 DHA M261 inulin 2.5% fibact Mutanen 00->10837006 0.7 1 35 49 140 1.8 2.4 133 1.0 5.5 Inulin M262 meat beef 24% other Mutanen 00->10837006 0.7 1 35 53 150 1.8 3.2 178 0.8 5.5 meat M263 rye bran water extract 8% fibact+ Oikarinen 03->12844383 0.7 2 31 44 142 * 0.5 1.0 200 * 0.7 6 rye M264 retinoic ac. allTrns /+PhIP 50ppm vitAD+ Mollersen 04->14514656 0.7 1 99 142 143 * 0.9 1.5 167 0.9 7 tum.size x1.56 M265 sulindac /Apc1638 200ppm NSAI Itano 04 0.7 1 1 0 0 * 0.0 0.9 9200 * 0.0 26 incidence data M266 folic acid defic.0.3 vs.2ppm /min Mthfr+/ñ vitB+ Lawrance 07->16963246 0.7 2 32 48 149 * 10 /+23 folic deficiency M267 wheat Araphoe, whole 50% fibact+ Drankhan 03->15087272 0.7 1 24 36 155 0.6 0.4 78 2.0 10 low orthophenolic wheat M268 CD4+45RBhi lymphocytes 3x10E5 other+ Rao Pouta. 06->16397216 0.6 1 57 91 160 * once lym M269 vegetables-fruits mix. 22% in 20%fat phyto VanKranen 98->9771930 0.6 2 17 28 162 * 1.5 2.3 152 1.1 16/-3 Veg M270 rye bran /female 30% phyto+ VanKranen 03->12881015 0.6 1 60 101 170 * 2.0 1.9 95 1.8 10 high lignans M271 ranolazine 2x30mg/kg/d ip other+ Suckow 04->15159018 0.6 1 12 20 169 * 4 ran M272 high-fat low-Ca 21-0.1vs.11-0.6% /Mlh1 fat+ Tsao Dudley 02->12419828 0.6 1 2 3 173 * 43 fat M273 flaxseed 5% phyto+ VanKranen 03->12881015 0.5 2 5 9 192 * 0.4 0.7 160 1.2 4 high lignans & isoflavones M274 GW501516 PparDelta 10mg/kg Ppar+ Gupta RA 04->14758356 0.5 1 28 55 193 * 1.4 1.7 121 1.6 6 5x increase in polyps >2mm M275 Western diet highFat lowCa /min-p21-- fat+ Yang Mathew 01->11212250 0.5 1 4 7 192 * 36 75% deaths in W.d. fed p21-- M276 fructo-oligosacch. 5.8% inT-cell depletd fibact Pierre 99->10506110 0.5 1 0.4 0.8 200 * 6 FOS M277 PhiP 10mg/kg x 1 inj. HAA Steffensen 01->11751386 0.5 2 47 88 188 * 0.6 0.9 157 1.2 9 PhiP M278 prostaglandin E2 2x 300mcg/d po other+ Wang Wang 04->15380519 0.5 1 50 101 200 * 0.3 2.2 667 * 0.3 7 PGE2 incr. Polyp size M279 starch resistant- /Apc1638 20% fibact+ Williamson 99->10334197 0.5 1 1.52 3 213 * 20 RS= H7+pota M280 retinoic acid allTrans 10ppm vitAD+ Mollersen 04->14514656 0.4 1 18 42 232 * 0.3 1.5 500 * 0.5 7 tum.size x1.2 M281 Western diet highFat lowCa /p27kip1 fat+ Yang Bancr. 03->12941825 0.4 1 1 3 246 * 36 tumors in wild mice fed W.diet M282 PhiP /Apc1638 0.03% male&fem. HAA Sorensen 97->9111214 0.4 1 3 7 234 * 26 PhiP M283 western diet Fat+ Ca- vit.D-/Apc1638 fat Yang Edelm. 98->9865728 0.4 2 1.0 2.3 233 14-34 West M284 Western diet vs AIN76 highFat lowCa fat+ Yang Mathew 01->11212250 0.4 1 2 4 253 * 36 25% deaths in W.d. fed min M285 X-irradiation 2Gy once other+ Okamoto 05->15802863 0.4 1 78 210 270 * 3.5 16.8 480 * 0.6 once 11d Xray M286 N-OH-PhiP /Apc716 50mg/kg x 5 inj. HAA Oshima 96->8561861 0.3 1 17 57 335 * 5d/+4 PhiP M287 PhiP 50mg/kg x 1 inj. HAA Steffensen 01->11751386 0.3 2 47 163 346 * 0.6 1.8 297 * 1.2 9 PhiP M288 Western diet highFat lowCa + p21-- combi+ Yang Mathew 01->11212250 0.2 1 2 7 418 * 36 75% deaths in W.d. fed p21-- M289 folate /MinMsh2-- 8ppm vitB Song Sohn 00->10866310 0.2 1 70 295 422 * 2.4 2.4 100 4.2 5 /+6 Folate M290 PhiP 25mg/kg x 8 inj. HAA Andreassen 01->11420398 0.2 1 30 157 524 * 0.6 0.9 145 3.6 pups 3 PhiP M291 PhIP 50mg/kg 1sc.Inj. HAA+ Mollersen 04->14514656 0.2 1 18 99 551 * 0.3 0.9 300 * 1.8 pups PhIP M292 sulindac /Mlh1 200ppm NSAI Itano 04 0.1 1 0 0 315 0.1 0.9 1517 * 0.2 26 incidence data M293 PhiP 50mg/kg x 8 inj. HAA Andreassen 01->11420398 0.1 1 30 237 789 * 0.6 3.1 519 * 1.5 pups 3 PhiP M294 DSS 4% in water other Cooper 01->11729120 0.0 2 1.7 24.2 1421 * 1 DSS